David Huntsman

David Huntsman MD, FRCPC, FCCMG

Chief Medical Officer

Dr. Huntsman’s expertise is in the translation of genomics into assays leading into improved cancer control, which demands complementary expertise in the development and delivery of novel assays as well as discovery genomics. In addition to leading cutting-edge research in the discovery and development of biomarkers and therapeutic targets for ovarian and rare cancers, Dr. Huntsman leads British Columbia’s multidisciplinary ovarian cancer research team. Dr. Huntsman’s group has a long track record of taking discoveries from basic genomic research into large cohorts of clinically annotated samples to determine their clinical relevance followed by clinical implementation.

Select Publications

Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer

Moledulcar Profiling and Molecular Classification of Endomeroid Ovarian Caricnomas

Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Overian Cancer Risk

Histone Deacetylase Inhibitors Synergize with Catalytic Inhibitors of EZH2 to Exhibit Antitumor Activity in Snall Cell Carcinoma of the Ovary, Hypercalcemic Type

Expression of L1 RetroTransponson Open Reading Frame Protein1 in Gynecologic Cancers

The Molecular Pathology of Cancer: from Pan-Genomics to Post-Genomics

Pontanib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) Through Multikinase Inhibition

Clear Cell Carinomas of the Ovary and Kidney; Clarity Through Genomics

SWI/SNF Complex Mutations in Gynecologic Cancers: Molecular Mechanisms and Models

Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Manamgement Guidelines

Characteristics and Outcome of the COEUR Canadian Validation Cohort for Ovarian Cancer Biomarkers

Non-Coding Somatic Mutations Converge on the PAX8 Pathway in Ovarian Cancer

Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Arginnisuccinate Synthase Deficient Ovarian Cancer, Including Small Cell Carcinoma of the Ovary, Hypercalcemic Type

TERT Promoter Mutation in Adult Granulosa Cell Tumor of the Ovary

Distinct Development Trajectories of Endometriotic Epithelium and Stroma: Implications for the Origins of Endometriosis