
Samuel Aparicio MB, BCH, PhD, FRCPath, FRSC
Chief Scientific Officer
Dr. Aparicio graduated in medical and natural sciences from Cambridge University (UK) and clinical medicine from Oxford University (UK). He trained in internal medicine and anatomic pathology. From 2000-2005, Dr. Aparicio was a senior investigator in the Department of Oncology, Cambridge. He co-founded (1999) the UK and Singapore-based biotech company Paradigm Therapeutics (now Takeda Cambridge), where he was Director of Science until 2004. Dr. Aparicio is currently the Nan and Lorraine Robertson Chair of Breast Cancer Research, based at UBC/BC Cancer Agency, Vancouver, Canada, and a Canada Research Chair in Molecular Oncology. His work encompasses the fields of cancer evolution, single-cell genomics, mouse genetic models, high throughput screens, and translational breast cancer research.
- Select Publications
-
Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing
Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer
Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups
Probabilistic cell-type assignment of single-cell RNA-seq for tumor micro-environment profiling
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes
Scalable whole-genome single-cell library preparation without pre-amplification