Sohrab Shah PhD

Chief Informatics Officer

Sohrab Shah is the Chief of Computational Oncology at Memorial Sloan Kettering Cancer Center. He is a Senior Scientist in the Department of Molecular Oncology, British Columbia Cancer Agency, and an Associate Professor, Department of Pathology and Laboratory Medicine, University of British Columbia. Dr. Shah holds the Canada Research Chair in Computational Cancer Genomics and is a Susan G. Komen Scholar.

Dr. Shah received his Ph.D. in computer science from the University of British Columbia and has over 12 years of innovating practical bioinformatics solutions for genomics of human cancer. His seminal works include the world’s first fully sequenced epithelial cancer genome, the discovery of new cancer gene mutations, global leadership in cancer evolution, and subgroup discovery in ovarian and breast cancer.

Select Publications

Probabilistic Cell-type Assignment of Single-Cell RNA-Seq for Tumor Microenvironment Profiling

Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell genome Sequencing

Dissociation of Solid Tumor Tissues with Cold Active Protease for Single-Cell RNA-Seq Minimizes Conserved Collagenase-associated Stress Responses

Eleven Grand Challenges in Single-Cell Data Science

Clonealign: Statistical integration of Independent Single-Cell RNA and DNA sequencing data from Human Cancers

Copy Number Signatures in Ovarian Cancer

Somatic Mutation Detection and Classification through Probalistic Integration of Clonal Population Information

Integrated Structural Variation and Point Mutation Signatures in Cancer Genomes Using Correlated Topic Models

Non-Coding Somatic Mutations Converge on the PAX8 Pathway in Ovarian Cancer

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